Science-Based Benefits of Nicotinamide (NR and NMN)

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are precursors of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular processes such as energy production, DNA repair, and metabolic regulation.

As we age, NAD+ levels decline, leading to various age-related problems. Supplementation with NR and NMN has shown promising benefits for health, aging, and disease prevention.

1. Increases NAD+ levels and cellular energy production

Both NR and NMN directly increase NAD+ levels, which are critical for mitochondrial function and energy production. Studies have shown that supplementation with NR or NMN effectively increases cellular energy, supporting overall metabolic health [1] and increasing endurance during physical activities [2].

2. Anti-aging and longevity

NAD+ plays a role in activating sirtuins, proteins associated with aging and longevity. Supplementation with NMN and NR may slow the age-related decline in NAD+ levels, thereby reducing the physical signs of aging.

Research shows that taking NMN over time can mitigate age-related physiological decline by improving physical activity, metabolic health, and even eye function without significant side effects. [3].

3. Neuroprotection and cognitive health

NMN and NR have been found to support cognitive health by protecting neurons and maintaining NAD+ levels in the brain, which may be beneficial in preventing neurodegenerative diseases.

Studies reveal that NR supplementation has a protective effect against neurodegenerative conditions by maintaining cellular NAD+ levels, which may slow cognitive decline. [4].

4. Cardiovascular health

NMN and NR supplementation has been shown to improve cardiovascular health by supporting endothelial function and reducing inflammation. These compounds help maintain NAD+ levels, thereby improving blood vessel function and reducing markers of inflammation, which are critical for preventing cardiovascular disease. [5].

5. Muscle health and physical performance

NR and NMN are beneficial for muscle health by aiding cellular repair and improving muscle endurance. Studies have shown that these compounds increase NAD+ levels in muscles, protecting them from age-related muscle decline and improving exercise capacity. [6].

6. Immune system support and anti-inflammatory effect

NR promises to support immune system health by increasing NAD+ levels, which are crucial for immune cell function. This is especially important in fighting infections, as NAD+ levels support immune responses and reduce systemic inflammation [7].

7. Potential for Diabetes Management

By increasing NAD+ levels, NMN has been linked to improved insulin sensitivity and better metabolic function, which may help manage diabetes. Animal model studies have shown that NMN supplementation improves glucose tolerance and insulin sensitivity, suggesting it may be a beneficial supplement for people with metabolic disorders. [8].

Longevity with nicotinamide

Overall, NR and NMN supplements offer scientifically supported benefits for aging, cardiovascular, cognitive, muscular, and immune health. By increasing NAD+ levels, these compounds help maintain cellular health and reduce age-related decline, supporting longevity and overall well-being.

Dr. Andrew Huberman (a scientist and professor at Stanford University) includes nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) in his diet to increase NAD+ levels, which play an essential role in cellular energy production, DNA repair, and maintaining overall vitality.

He takes 500 mg of NR and 1-2 grams of NMN daily, primarily to maintain mental and physical energy, not for longevity benefits. He has noticed that these supplements provide a steady burst of energy that doesn’t interfere with his sleep, making it easier to stay active and focused throughout the day.

The NR-A nutritional supplement from DR-D Longevity

Dr. D Longevity’s NR-A offers a high-quality source of nicotinamide riboside (NR), an advanced precursor to NAD+ known for its anti-aging, energy-boosting, and cell-repairing properties.

Scientific research supports the potential benefits of NR for improving metabolic health, cognitive function, cardiovascular health, and muscle performance. This supplement is especially beneficial for people looking to counteract the age-related decline in NAD+ levels, a key factor in cellular energy production and longevity.

With a powerful NR formula and a commitment to purity, NR-A positions itself as an incredible option for those seeking to maintain their long-term health and vitality through evidence-backed NAD+ supplementation.

Dr. D Longevity’s NR-A is the science-based choice for anyone interested in a targeted approach to aging and well-being.

Sources

1. Mehmel, M., Jovanović, N., & Spitz, U. (2020). Nicotinamide riboside—the current state of research and therapeutic uses. Nutrients. Retrieved from Consensus
2. Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., & Hu, M. (2021). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition.
3. Mills, K., Yoshida, S., Stein, L., Grozio, A., Kubota, S., Sasaki, Y., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism.
4. Ratajczak, J., Joffraud, M., Trammell, SAJ, Ras, R., Canela, N., Boutant, M., et al. (2016). NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nature Communications.
5. Mateuszuk, Ł., Campagna, R., Kutryb-Zajac, B., Kuś, K., Slominska, E., & Smolenski, R., et al. (2020). Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside. Biochemical Pharmacology.
6. Fletcher, R., Ratajczak, J., Doig, C., Oakey, LA, Callingham, R., & Da Silva Xavier, G., et al. (2017). Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Molecular Metabolism.
7. Biță, A., Scorei, IR, Ciocîlteu, M., Nicolaescu, O., Pîrvu, AS, Bejenaru, L., et al. (2023). Nicotinamide riboside, a promising vitamin B3 derivative for healthy aging and longevity: Current research and perspectives. Molecules. Retrieved from Consensus
8. Yoshino, J., Baur, J., & Imai, S. (2017). NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metabolism.

Disclaimer: This article is for informational purposes only and should not be considered medical advice. Please consult a qualified healthcare professional before taking any action regarding your health.